Oral Morphine

Morphine and morphine-glucuronide concentrations in plasma and CSF during long-term administration of oral morphine.

Concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured by h.p.l.c. in plasma and cerebrospinal fluid (CSF) samples from 16 patients with cancer receiving oral (controlled-release) morphine. There was a close correlation between plasma and CSF morphine concentrations (r = 0.94, P = 0.0001) and both correlated with drug dosage (r = 0.61, P = 0.013 ...

Comparison of Efficacy Between Oral Morphine Sulphate

Aim: to prospectively evaluate degree of pain during transrectal ultrasound-guided prostate biopsy after receiving analgesics treatment of oral morphine sulphate compared to suppository sodium diclofenac. Methods: the study group comprised 60 consecutive men subjects (median age 67.8 years) undergoing transrectal prostate biopsy. They were randomized into two groups; group 1 received oral analg...

Oral self-administration of morphine in rats.

A shortage of oral morphine in Egypt

A shortage of oral morphine in Egypt Samy A Alsirafy & Dina E Farag a Palliative Medicine Unit, NEMROCK, Kasr Al-Ainy School of Medicine, Cairo University, PO Box 99 Manial Al-Rodah, Cairo, 11553, Egypt. Correspondence to Samy A Alsirafy (email: [email protected]). (Submitted: 31 March 2015 – Revised version received: 28 September 2015 – Accepted: 29 September 2015 – Published online: ...

Oral Morphine Consumption Reduces Lens Development in Rat Embryos

Introduction: Consumption of morphine, during pregnancy, in addition to inducing defects in the mother’s nervous system function, caused defects or delays in the formation and evolution of embryonic visual system. In the present study, changes in lens development were assessed in embryos exposed to morphine in utero. Methods: Female Wistar rats (250-300 g) were mated with male rats and pregnanc...